Vaginal intraepithelial neoplasia (VaIN) is a precancerous condition that affects the vaginal epithelial cells. It is caused by a human papillomavirus (HPV) infection, and it is the most common precancerous condition in the genital tract of women. The most commonly affected age group is women between the ages of 30 and 50. VaIN is characterized by an abnormal growth of the epithelial cells in the vagina. This abnormal growth can lead to an increased risk of developing cancer, as the abnormal cells are more likely to become cancerous. Symptoms of VaIN can include abnormal vaginal bleeding, itching, and an unusual discharge. Diagnosis of VaIN is typically done through a physical exam and pap smear. A biopsy may be necessary to confirm the diagnosis. Treatment typically involves the use of topical medications, such as antiviral medications or topical retinoids. In some cases, a procedure called laser ablation may be used to remove any abnormal cells. It is important for women to be aware of VaIN as it can lead to an increased risk of developing cancer. Regular pap smears and pelvic exams can help to identify any abnormal cells and early treatment can help to reduce the risk of developing cancer.