The era of one-size-fits-all medicine is being replaced by tailored approaches that consider genetic, molecular, and lifestyle variables. Precision medicine in gynecology leverages genomic data, biomarker profiling, and digital health insights to customize care across reproductive and oncologic conditions. This methodology is especially impactful in the management of endometrial and ovarian cancers, where molecular subtyping informs prognosis and treatment choices. Fertility preservation strategies, hormonal therapies, and even preventive screenings are being personalized based on individual risk profiles. Integrating patient-specific data allows clinicians to minimize adverse effects and optimize outcomes. Precision medicine in gynecology represents a shift from reactive to predictive care, aligning interventions with a woman’s unique biology and life circumstances. As research advances, precision frameworks are set to redefine every stage of gynecologic practice.