Comprehensive STI prevention strategies remain vital in gynecologic practice and global health. Sexually transmitted infections and prevention focuses on reducing transmission, improving early detection, and promoting public education around safer sexual practices. The burden of infections such as HPV, chlamydia, and HIV continues to affect women disproportionately, particularly in regions with limited access to healthcare. Advances in diagnostic tools, such as point-of-care testing and self-sampling kits, are improving reach and confidentiality. Vaccination programs and pre-exposure prophylaxis (PrEP) have also become essential components of modern prevention strategies. Culturally tailored interventions and stigma reduction efforts are equally crucial in encouraging screening and treatment adherence. Sexually transmitted infections and prevention represents a holistic public health priority that integrates science, education, and policy to safeguard women's sexual and reproductive well-being.