Pre-implantation genetic diagnosis (PGD) is the process of evaluating embryos or oocytes for genetic abnormalities before they are implanted. It was created for couples who are concerned about severe Mendelian disorders, structural chromosome abnormalities, or mitochondrial illnesses in their offspring. In vitro fertilisation, embryo biopsy, and either fluorescence in situ hybridization or polymerase chain reaction at the single cell level are required for pre-implantation embryo diagnosis. As a result, it is a difficult technique that necessitates a great deal of expertise. Preimplantation genetic testing is a set of genetic tests performed to assess embryos before they are implanted in the uterus. Preimplantation genetic testing-monogenic is a narrower test that looks for aneuploidy in all chromosomes, including the 22 pairs of autosomes and the sex chromosomes X and Y. Preimplantation genetic testing-aneuploidy is a broader test that looks for aneuploidy in all chromosomes, including the 22 pairs of autosomes and the sex chromosomes X and Y. Preimplantation genetic testing-structural rearrangements is used to screen embryos for chromosome gains and losses caused by parental structural chromosomal abnormalities (e.g., translocations, inversions, deletions, and insertions).
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