Recurrent Pregnancy Loss (RPL) is a clinically challenging reproductive condition, and in a significant proportion of patients no identifiable cause is found using standard diagnostic work-up. Increasing clinical and experimental evidence suggests that endometrial dysfunction rep [....] » Read More
The integration of thread technology into gynecological practice represents a significant advancement in both aesthetic and functional treatment modalities. Originally utilized in dermatology for facial rejuvenation, absorbable threads such as polydioxanone (PDO), poly-L-lactic a [....] » Read More
Objective: To quantify safety and 6-month effectiveness of non-ablative Radiofrequency (RF) on symptoms of Pelvic Floor Dysfunction (PFD) and Genitourinary Syndrome of Menopause (GSM) in women seeking intimate anti-aging. Methods: Three centres enrolled 208 women (45-65 y) wit [....] » Read More
Background: Periodontitis is inflammation of the periodontium that extends beyond the gingiva and produces destruction of the connective tissue attachment of the teeth. Maternal oral health is very important factor in determining pregnancy outcome not only for the mother but a [....] » Read More
Monitoring fetal wellbeing during pregnancy and parturition has always been challenging. Various modalities have been discussed since time immemorial. Electronic fetal monitoring (EFM)has been introduced since 1970 and has been an integral part of obstetric practice. Newer techni [....] » Read More
Background: The G Protein-Coupled Estrogen Receptor (GPER) is a non-genomic estrogen receptor widely expressed in Breast Cancer (BC). Its role extends beyond simple estrogen signaling, linking drug resistance with Tumor Microenvironment (TME) remodeling. Methods: We systematic [....] » Read More
Background: Abdominal Sacrocolpopexy (ASC) is the gold standard surgical procedure for vaginal vault prolapse. Although synthetic mesh provides excellent anatomical support, concerns regarding mesh-related complications have led to renewed interest in biologic grafts such [....] » Read More
Uterine manipulator helps the surgeon to hold uterus, in a desired position, for cutting it from its attachments. It also keeps important structures away from the energy sources and protect them. The advantages of manipulator are Good visualisation. Keep Bladder, bowel and ureter [....] » Read More
A 33-year-old woman (G3P2+1) presented with a three-year history of progressive hirsutism, significant weight gain, and secondary amenorrhoea, initially attributed to polycystic ovarian syndrome (PCOS) in the context of a raised serum testosterone (6.3 nmol/L) and concurrent hypo [....] » Read More
Introduction: Same-day theatre cancellations (SDTCs) remain a major challenge within the NHS, negatively affecting patient experience, workforce efficiency, theatre utilisation, and healthcare costs. Recent UK data from the PACE2024 study demonstrated cancellation rates of app [....] » Read More
Background/Objectives: Outpatient hysteroscopy is the gold standard for uterine investigation per RCOG Green-top Guideline 59 (2024). This retrospective audit evaluated compliance with GTG 59 at Ysbyty Glan Clwyd, North Wales, focusing on outpatient success rates, day-case e [....] » Read More
Background: Existing data quantify maternal deaths but lack hospital-based evidence on barriers and determinants affecting ANC and FANC utilization. This mixed-methods study used a structured questionnaire to assess barriers, stigma, and factors affecting ANC and FANC use among p [....] » Read More
Male infertility is one of the major challenges in reproductive health worldwide and, in many cases, has a multifactorial and complex etiology. In recent years, oxidative stress and inflammation have been recognized as two pivotal mechanisms involved in the onset and progression [....] » Read More
Objectives: Human Papillomavirus (HPV) is the major etiological agent of cervical cancer, a leading cause of morbidity and mortality in women worldwide; screening strategies for reducing the burden of HPV-mediated carcinogenesis are emerging as effective means for cervical c [....] » Read More
The perinatal period is a high-risk time for women with mental health conditions, particularly post-partum. To support early identification and timely support, national and local guidance recommend the use of a birth plan. Pennine Specialist Perinatal Community Mental Health Team [....] » Read More
Background: Selecting an appropriate contraceptive method is often a dynamic, trial-and-error process shaped by medical, behavioral, and contextual factors. Although side effects and early discontinuation are common among healthy women, those living with benign gynecological [....] » Read More
Background: IgG4-related sclerosing mastitis (IgG4-RSM) is an exceptionally rare manifestation of IgG4-related disease that can closely mimic breast carcinoma or lymphoma. Because imaging findings are frequently suspicious and nonspecific, affected patients may undergo extensive [....] » Read More
Background: Thoracic endometriosis syndrome (TES) is a rare extrapelvic manifestation of endometriosis that may present with recurrent pneumothorax, hemothorax, hemoptysis, or pulmonary lesions. Because symptoms often overlap with common thoracic conditions, diagnosis may be dela [....] » Read More
In Bio-restorative medicine, regenerative science is utilized to treat underlying pathologies such as atrophy, chronic inflammation and pelvic floor dysfunction. Regenerative gynecology is focused on restoring the function and anatomy of female reproductive organs using the body& [....] » Read More
Parity is associated with GS only in younger mothers. High estrogen levels, mainly in the last trimester, increases cholesterol saturation of bile and high progesterone levels during all P reduce gallbladder contractility, both phenomenon may help sludge and GS precipitatio [....] » Read More
Historically peritoneum has been a neglected anatomical structure, however recent research identifies it as an important functional organ. Apart from lining and protecting the abdominal organ it plays a major role in tissue repair, immunological response and tissue regeneration. [....] » Read More
High-risk pregnancy is often associated with increased emotional and psychological challenges because of the added concerns regarding maternal and fetal health. Despite the growing recognition of maternal mental health as an important component of prenatal care, limited local stu [....] » Read More
Those stories showcase the obstacles women in rural areas of Nepal have to face throughout their journey to motherhood. Geographical barriers in remote areas pose immense challenges in accessing healthcare facilities. The lack of transportation infrastructure and difficult t [....] » Read More
Background: The number of minimally invasive procedures for the functional rejuvenation of the internal genitalia has increased sharply in recent years. Barbed suture threads composed of biodegradable materials represent a promising approach; however, their histological effe [....] » Read More
Background. The number of minimally invasive procedures for the functional rejuvenation of the internal genitalia has increased sharply in recent years. Barbed suture threads composed of biodegradable materials represent a promising approach; however, their histological effect on [....] » Read More
Background: Dedifferentiated endometrial carcinoma (DEC) is a rare and aggressive uterine malignancy. Its synchronous occurrence with uterine leiomyosarcoma as a collision tumour is exceptionally uncommon and has important diagnostic and therapeutic implications. Case Presenta [....] » Read More
Background: Miscarriage is one of the most common complications of early pregnancy, affecting approximately 1 in 5 pregnancies, with the majority occurring during the first trimester. The National Institute for Health and Care Excellence (NICE) quality standards aim to improve th [....] » Read More
The exploration and management of infertility are evolving daily thanks to advances in understanding and in exploration and treatment techniques. However, the place of endometrial assessment is not well defined in the decision-making pathway of IVF. In the different international [....] » Read More
Background: Hyperprolactinemia is a common endocrine disorder that affects reproductive health and has increasingly been linked with immune dysregulation. Although prolactin is recognized for its immunomodulatory functions, the relationship between elevated prolactin levels and a [....] » Read More
Women’s healthcare has evolved remarkably over the last two decades, shifting from a disease-centred approach to a comprehensive life-course model that addresses physical, reproductive, psychological, sexual, and oncologic wellbeing. Contemporary gynaecologic practice now e [....] » Read More
Indian females from the interior and mostly from hilly area are illiterate agricultural laborers. Pregnant females of these distant areas cannot visit for regular antenatal checkups and have folic acids, iron, and vitamins. These deficiencies may lead to neural tube defects, open [....] » Read More
Sexual assault remains significantly underreported in healthcare settings, yet gynecologic environments are one of the most common places where disclosures occur. Despite this, screening practices vary widely, and many clinicians express discomfort, uncertainty, or concern about [....] » Read More
Background: Urinary Incontinence (UI) is a major symptom of pelvic floor dysfunction in women and commonly develops during pregnancy and childbirth. Approximately 40% of women experience UI in the early postpartum period, and symptoms may persist long term, making UI a signi [....] » Read More
Title : Pathologic findings in women with atypical glandular cells on Pap test
Neda Zarrin Khameh, Baylor College of Medicine, United States
Introduction: It has been shown that a significant subset of Atypical Glandular Cells (AGC) indicates underlying malignancies. Therefore, it is imperative to recognize, diagnose, and treat these lesions early. We evaluated the clinical significance of AGC on cervical cytolog [....] » Read More
Title : Exploitation of sperm agglutination factor derived from Staphylococcus aureus as a putative candidate for vaginal contraception
Vijay Prabha, Panjab University, India
Vaginal contraception is perhaps the oldest method of fertility regulation that has been practiced over the centuries. With minimal systemic involvement, it is also one of the safest methods of contraception. The use of vaginal contraceptives as local agents in a need-based manne [....] » Read More
Title : Pregnancy outcome after uterine artery embolization for uterine adenomyosis: A systematic review and meta-analysis
Mohamed M Hosni, London North West University Healthcare NHS Trust, United Kingdom
Background: Uterine adenomyosis involves the growth of endometrial gland and stroma within the uterine musculature. Patients, with uterine adenomyosis, experience heavy painful periods, deep dyspareunia and subfertility, reducing their overall quality of life. Hysterectomy is usu [....] » Read More
Title : Inositol in treating subfertile women and adolescents with PCOS
Lalit Bora, Obstetric and Gynaecological Societies, India
Polycystic ovarian disease is one of the most common endocrine disorders affecting women of reproductive age and adolescents. It doesn’t spare even perimenopausal women. PCOS is the most common cause of anovulatory infertility in women. The global prevalence of PCOS varie [....] » Read More
Title : What they don’t teach you about fibroids, the clinical gaps that fail patients every day
Ruthie Olumba, Aurdena Femme, United States
Despite the prevalence of fibroids worldwide, clinicians still face significant gaps in training that affect diagnosis, counseling, and long term management. In my years as a reproductive surgeon and fibroid specialist, I have seen how women living with fibroids struggle when [....] » Read More
Title : Comparing multiple measures of body mass as predictors for testosterone and estradiol levels in men
Kayla Schacher, SUNY Downstate Health Sciences University, United States
Background: Prior studies have shown that increased body mass in men is associated with decreased levels of testosterone and increased levels of estradiol. These hormone alterations can lead to fertility issues. Body mass can be measured as body mass index (BMI, kg/m2), waist [....] » Read More
Title : Optimising endometrial protection in patients using high-dose transdermal oestrogen: A primary care quality improvement project
Holly West, Manchester University NHS Foundation Trust, United Kingdom
Background: Women and people with an intact uterus receiving systemic oestrogen require adequate progesterone to reduce the risk of endometrial hyperplasia and carcinoma. Updated British Menopause Society guidance recommends increased progesterone doses for women using highe [....] » Read More
Title : Genomic signatures of mucinous ovarian tumours with mural nodules: Distinguishing features from mucinous tumours without mural nodules and dedifferentiated mucinous carcinoma
Jasenka Mazibrada, Norfolk and Norwich University Hospital, United Kingdom
Aim: To investigate the molecular events underlying Mucinous ovarian Tumours with Mural Nodules (MTMN) and compare them with mucinous tumours without mural nodules, with attention to differential diagnosis against Dedifferentiated Mucinous Carcinoma (DDMC). Methods: Targete [....] » Read More
Title : Efficiency of IVF programs in women of late reproductive age when assessing the mitotic spindle
Elena Vladimirovna Kozyreva, Moscow Academic IVF Clinic, Russian Federation
Late reproductive age, poor oocyte quality, and aneuploid embryos remain a pressing issue in modern IVF. The search for possible solutions to this problem continues. The quality of the embryo and its developmental potential depend on the quality of the oocyte. Typically, the cell [....] » Read More
Title : Comparing postoperative complications and outcomes between minimally assisted vs open abdominal hysterectomy for women with cervical cancer
Nisha Bhavin Thanki, Barts and The London School of Medicine and Dentistry QMUL, United Kingdom
Background: Cervical cancer remains a leading cause of mortality, being the fourth most common cancer affecting women worldwide. While radical hysterectomy remains the mainstay approach to treat early-stage cervical cancers, the surgical approach remains a point of clinica [....] » Read More
Title : Transperineal ultrasound in labour: Bridging the gap between evidence and UK practice
Junaid Rafi, The Princess Alexandra Hospital NHS Trust, United Kingdom
OBJECTIVE: Transperineal ultrasound (TPU) is an emerging, evidence-based modality for intrapartum assessment, providing objective and reproducible parameters such as Angle of Progression (AoP), Head–Perineum Distance (HPD), and Midline Angle (MLA). Despite robust internatio [....] » Read More
Title : Exploring the experiences and perceptions of black and ethnic minority pregnant women with fibroids in England: An interpretative phenomenological analysis
Zahrah Binthabit, University of Salford, United Kingdom
Background and Aims: Black and ethnic minority women have a higher prevalence of uterine fibroids, which cause adverse pregnancy outcomes, including preterm birth and caesarean delivery, and psychosocial burden. Although equity is a commitment of NHS England and Wales, there [....] » Read More
Title : Examining the impact of advanced paternal age on obstetrical and fetal outcomes
Sakshi Das, State University of New York Downstate College of Medicine, United States
Background: Advanced paternal Age (APA), defined as 40 years or older at time of conception, is associated with poor outcomes with assisted reproductive technologies. Review of literature suggests APA may be associated with infertility, miscarriage, preterm delivery, and plac [....] » Read More
Title : Promoting mitocytosis via gene-engineered aligned fibers for pelvic floor reconstruction
Xinliang Chen, Shanghai Jiao Tong University, China
Severe Pelvic Organ Prolapse (POP) relies primarily on pelvic floor reconstructive surgery for repair. Polypropylene mesh, currently the mainstay in clinical practice, is associated with poor biocompatibility and serious surgical complications, leading to safety warnings and sale [....] » Read More
Title : Carbetocin versus conventional uterotonic regimens for prevention of blood loss after vaginal and cesarean delivery: A retrospective study in a Taiwanese low-risk obstetric population
Ming Han Chang, Shuang Ho Hospital, Taiwan, China
Background: Postpartum Hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality worldwide, with uterine atony being the primary underlying etiology. Although oxytocin is the standard prophylactic uterotonic agent, carbetocin, a long-acting oxytocin analog [....] » Read More
Title : A simple bedside composite risk score (AB-100 rule) for predicting cesarean birth in nulliparous women: A historical cohort study with external validation
Shih Peng Mao, Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare, Taiwan, China
Background: Cesarean birth rates continue to rise worldwide. Advanced maternal age and elevated Body Mass Index (BMI) are well-established risk factors for intrapartum cesarean delivery in nulliparous women. However, translating these epidemiological risk factors into a simp [....] » Read More