Title : Evaluation of Long non-coding RNA (LncRNA) involved in chemotherapy resistance in cervical cancer: Molecular approach
Abstract:
Cervical cancer (CC), caused by human papillomavirus (HPV), is a leading cause of female malignancies worldwide. Therefore, understanding the underlying mechanisms of CC development and identifying novel therapeutic targets are significantly important. While research efforts have largely focused on oncogenes and protein-related signaling pathways involved in CC development, the efficacy of cisplatin, a widely used drug for CC treatment is compromised. Cisplatin resistance is a significant challenge in the management of CC. Recent studies highlighted the critical role of long non-coding RNAs (lncRNAs) in modulation of cisplatin resistance. This comprehensive review aims to collect the current understanding roles of lncRNAs and their involvement in cisplatin resistance in CC by highlighting key processes of cancer progression, including apoptosis, proliferation, angiogenesis and epithelial-to-mesenchymal transition (EMT). In this review insights into potential therapeutic targets and strategies to overcome cisplatin resistance in CC was introduced. In conclusion, this review emphasis the significance of lncRNAs in mediating cisplatin resistance in CC. Explaining the complex relevance of lncRNAs in induction of the cisplatin resistance associated pathways could pave the way for the development of innovative therapeutic approaches aimed at improving CC treatment outcomes.
Keywords: Cervical Cancer, LncRNA, Cisplatin Resistance, Proliferation, Apoptosis, Angiogenesis.
