Title : A Rare case of uterine embryonal Rhabdomyosarcoma in an old patient
Abstract:
Background: Uterine embryonal rhabdomyosarcoma is an aggressive mesenchymal tumor that is exceptionally rare in adult patients. Due to its infrequent occurrence, there are no standardized guidelines for its diagnosis and management.
Case: A 57-year-old woman presented with worsening intermittent bleeding over 4 to 5 years, initially managed as fibroids. MRI revealed an enlarged uterus with a large fibroid. An endometrial biopsy was inconclusive, and treatment with Leuprolide offered only temporary relief. Due to persistent symptoms and a significant uterine enlargement, suspicion of malignancy arose. Subsequent biopsies indicated high-grade malignancy, leading to a diagnosis of uterine embryonal rhabdomyosarcoma following hysterectomy. She is now undergoing chemotherapy with Docetaxel and Gemcitabine.
Conclusion: This study highlights the importance of maintaining a high index of suspicion and thorough diagnostic evaluation in cases of abnormal uterine bleeding and fibroid growth to identify rare malignancies like uterine embryonal rhabdomyosarcoma. Further research is needed to establish the optimal diagnostic approach to occult uterine sarcomas generally and the management of uterine rhabdomyosarcoma.
