Evaluation the relationship between the type and severity of pain, and the anti mullerian hormone with the endometriosis stage

Title : Evaluation the relationship between the type and severity of pain, and the anti mullerian hormone with the endometriosis stage

Abstract:

Objective: Endometriosis is a chronic disease of the female reproductive system, and is one of the causes of chronic pain and infertility in women of fertility age. This paper aims to investigate the relationship between the type and severity of pain and the level of the Anti-Mullerian hormone (AMH) with the stage of Endometriosis.

Methods and Materials: In this descriptive-analytical cross-sectional study, endometriosis patients referring to the public and private endometriosis clinics of Mashhad, IRAN during a year (2018 to 2019) were examined. Patients’ information: type of pain (dysmenorrhea, dyspareunia, dyschezia, and non-cyclic pain), pain severity, and AMH levels were recorded. The stage of the disease was also specified based on the ASRM score (according to surgery or MRI). Then, the type and severity of pain and AMH level were compared with the disease stage in each patient. A significance level of 0.05 was considered meaningful.

Results: 160 patients were included in the study. In investigating the relationship between the type of pain with disease's stage; only dyschezia had a significant relationship (P= 0.02). However, in the study of the relationship between pain's severity with the disease stage, the severity of dysmenorrhea and dyspareunia significantly increased with the progression of the disease (P< 0.05). The highest serum AMH level in stage 2, and the lowest level in stage 3 of disease were found. But no significant relationship was found between the level of this hormone and the stages of the disease (P> 0.05).

Conclusion: The results of this study revealed that the severity of dysmenorrhea and dyspareunia in endometriosis could indicate a more advanced stage of the disease. But AMH level is not a good indicator to estimate severity and type of disease.

Keywords: endometriosis, Anti Mullerian Hormone, Dysmenorrhea, Dyschezia, Pelvic Pain, dyspareunia, Cyclic Pain

Biography:

Dr.Nona Sabeti, completed her general medical education at Mashhad University and immediately started her residency. Currently, she is serving as the Chief Resident in the Department of Obstetrics and Gynecology. Her dedication and commitment to the field have helped her become a respected figure in specialty. She is passionate about research and have been actively involved in several research projects, contributing to the advancement of medical science. In addition to her clinical work, she have experience in genetic research and animal studies.