Title : Bioinformatics role in understanding reproductive disease and assisted reproductive treatment
Abstract:
Endometriosis is a gynecological condition that significantly impairs fertility, not only through anatomical distortion but also by altering the biochemical environment of the follicular fluid (FF), which plays a crucial role in oocyte quality. Inflammatory factors present in the FF of women with endometriosis are believed to negatively affect the developmental competence of oocytes, leading to fewer ovulations under natural conditions. This disruption contributes to the complex and multifaceted challenges associated with achieving pregnancy in affected individuals.
Ovarian stimulation protocols have emerged as a promising strategy to counteract this problem by rescuing and retrieving a greater number of oocytes, thus improving the likelihood of fertilization. However, it is now clear that simply addressing anatomical complications is not sufficient; the underlying molecular and inflammatory dynamics also need to be understood and targeted.
This presentation will explore the specific impacts of endometriosis on follicular fluid composition and the downstream effects on oocyte quality. Emphasis will be placed on how these insights can inform clinical strategies for early diagnosis and intervention. Timely referral to fertility treatment remains a key recommendation, as early therapeutic action has been associated with better reproductive outcomes.
Furthermore, this study highlights the potential for identifying specific proteins and biomarkers within the FF that may play distinct roles in the progression of endometriosis. These findings could pave the way for the development of novel, targeted treatments that go beyond symptomatic relief to directly address disease pathology.
While substantial progress remains to be made, this research contributes valuable preliminary data and reinforces the importance of molecular research in improving fertility outcomes for women with endometriosis.
