Title : Polymorphism FSHB gene was associated with age of menarche and obesity in women
Abstract:
The aim of this work was to study the correlation of the polymorphism FSHB gene (rs555621) with menarche age (AM) and obesity (Ob) in women of the Central Chernozem region of Russia. Material and methods. The sample for the study included 171 women (aged 20-30 years) of Russian nationality, living (born) in the Central Chernozem region of Russia (Belgorod region). In women, we assessed age, anthropometric indicators (height;weight;BMI), and AM. The SNP rs555621 FSHB was genotyped. Correlations between SNP and AM, Ob were studied using the gPLINK program. Results. Women with obesity are characterized by an earlier (by 0.7 years, p<0.001) onset of menarche. Using logistic regression analysis, it was found that early AM is a risk factor for obesity (OR= 0.49 [95% CI 0.34-0.71] p<0.001). The rs555621 FSHB was associated with the AM according additive (β = 0.233±0.116 pperm 0.05) and dominant (β = 0.357±0.170 pperm 0.05) models with correction for covariates (age and BMI). In women who have one or two G allele rs555621 in the genotype (genotypes AG and GG respectively), menarche occurs 0.34 years or 0.43 years later compared to women whose genotype does not have this allele (genotype AA). It was found that among obese women, the frequency of the AA rs555621 genotype is 2.01 times higher than in non-obese women (p=0.004). Also, the frequency of the rs555621 A allele is 1.32 times higher among obese women compared to non-obese women (p=0.009). These genetic variants are risk factors for Ob (OR=3.03 for genotype AA and OR=2.04 for allele A). The rs555621 FSHB is associated with the Ob in women (ORadditive =0.51 [95% CI 0.29 - 0.89] pperm 0.02) and ORdominant=0.38 [95% CI 0.18 - 0.79] pperm 0.009) with correction for covariates (age and AM).
