Relationship between serum VEGF, IL-6 levels and pregnancy outcome in patients with gestational diabetes

Title : Relationship between serum VEGF, IL-6 levels and pregnancy outcome in patients with gestational diabetes

Abstract:

Objective: To analyze the levels of serum vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in patients with gestational diabetes mellitus (GDM) and their relationship with pregnancy outcome.

Methods: 90 patients with GDM admitted to our hospital from January 2021 to December 2022 were selected as the observation group, and divided into good outcome subgroup and poor outcome subgroup according to different pregnancy outcomes, and 60 healthy pregnant women who underwent prenatal examination during the same period were selected as the control group. Serum levels of VEGF, IL-6, fasting blood glucose (FBG) and glycosylated hemoglobin (HbA_1C) were detected, the relationship between VEGF, IL-6 and FBG and HbA_1C was analyzed by Pearson correlation analysis, and the influencing factors of adverse pregnancy outcomes in GDM patients were analyzed by Logistic regression. Combined with the subject work characteristic curve (ROC), the predictive value of serum VEGF and IL-6 on adverse pregnancy outcomes in GDM patients was analyzed.

Results: Compared with the healthy control group, the serum levels of VEGF and IL-6 in observation group were significantly increased (P < 0.05). Among the 90 patients in the observation group, 62 cases had good pregnancy outcome and 28 cases had poor pregnancy outcome, with an adverse incidence of 31.11%. Moreover, the serum levels of VEGF and IL-6 in the poor outcome group were higher than those in the good outcome group, and the difference was statistically significant (P < 0.05). Pearson correlation analysis showed that VEGF and IL-6 were positively correlated with FBG and HbA_1C levels (VEGF: r = 0.435,0.483; IL-6: r = 0.486,0.472). Logistic regression analysis showed that high levels of VEGF, IL-6, FBG and HbA_1C were independent risk factors for adverse pregnancy outcomes in GDM patients [OR(95%CI)= 1.064(1.038 ~ 1.125), 1.072(1.028 ~ 1.134), 2.567(1.326 ~ 4.867), 2.378(1.474 ~ 3.586)]. ROC curve analysis showed that the AUC predicted by VEGF and IL-6 levels in GDM patients was 0.624 and 0.756, respectively, and the AUC predicted by the two levels combined was 0.831, which was higher than that predicted by alone (P < 0.05).

Conclusion: VEGF and IL-6 are independently correlated with adverse pregnancy outcomes in GDM patients, and the combined detection of serum VEGF and IL-6 levels has certain predictive value for adverse pregnancy outcomes in GDM patients.

Audience Take Away:

The combined detection of serum VEGF and IL-6 levels has certain predictive value for adverse pregnancy outcomes in GDM patients.

• Help the clinical physicians identify the very sick GDM patients timely.
• Help the clinical physicians give the proper treatment for such patients.

Biography:

Ms. Xiaoyan Peng is a doctor of Obstetrical department from Chongqing City. She borned in 1974 and have a undergraduate degree. She is now working in The People’s Hospital Tongliang District in Chongqing as a deputy chief physician.