Title : Improving oocyte quality in infertile women using mitochondrial replacement therapy, where do we stand?
Abstract:
Background: Mitochondrial Replacement Therapy (MRT) is an innovative and cutting-edge technique aimed at preventing the transmission of mitochondrial DNA (mtDNA) mutations from mother to child. Mitochondria, often referred to as the "powerhouses" of the cell, have their own DNA, and mutations in mtDNA can lead to severe, often fatal, mitochondrial diseases.
In some infertile women as well as older in Women age, the quality and quantity of their oocytes decline, and mitochondrial dysfunction is a key contributor to this decline. Mitochondria play a critical role in providing the energy required for oocyte maturation, fertilization, and early embryonic development. When mitochondrial function is compromised, it can lead to reduced ATP production, increased oxidative stress, and impaired developmental potential of the oocyte. MRT involves replacing defective mitochondria in an oocyte or embryo with healthy mitochondria from a donor. In the context of age-related infertility, this could potentially restore energy production and improve developmental competence.
How MRT Could Improve Oocyte Quality? Maternal Spindle Transfer (MST) and Pronuclear Transfer (PNT)
Challenges and Limitations: While MRT holds promise, there are several challenges and ethical considerations specific to its use for age-related infertility
Conclusion: MRT represents a promising but complex approach to addressing age-related infertility and poor oocyte quality. While significant challenges remain, ongoing research and technological advancements could pave the way for its safe and effective use in the future.
